By Ergo-Log
If you are looking for a slimming supplement, but don’t react well to supplements that knock the fatty acids out of your fat reserves by adjusting your adrenalin balance, then you might want to try Irvingia gabonensis. According to a molecular study done by African researchers, who have made it their business to know everything about the anti-obesogenic effect of Irvingia, the extract works in a completely different way.
The researchers published in 2009 the results of a study in which obese human subjects lost 10-12 kg weight in 10 weeks after taking Irvingia gabonensis. If the study is true, it’s sensational, and therefore it’s hardly surprising that the African extract is turning up in all sorts of slimming supplements.
A year before the Africans published their human study, the results of an experiment they carried out with fat cells from mice were published in Lipids in Health and Disease. This experiment showed exactly how Irvingia gabonensis works.
The researchers used 3T3-L 1 cells, which are cells that have not yet matured into fully adult fat cells. The researchers started by exposing the cells to insulin and other substances that induce fat cells to grow. After that the real experiment started: the cells were then exposed to different doses of the acids that occur naturally in Irvingia gabonensis.
The acids reduce the production of the PPAR-gamma protein by the fat cells. As a result of this the cells are less able to absorb fatty acids from the bloodstream and release their contents more easily into the blood. PPAR-gamma is a kind of sensor that enables fat cells to ‘see’ fatty acids. In addition, Irvingia reduces the production of leptin, but boosts the production of adiponectin.
Adiponectin is a ‘good’ fat hormone. Healthy, not too large fat cells synthesise adiponectin, which induces muscle cells to absorb more nutrients from the blood.
Leptin works in a more complex way. Slim people start to eat less if the concentration of leptin in their blood increases; fat people don’t react in this way. They often have high amounts of leptin in their blood but have become insensitive to the hormone.
Source:
Lipids Health Dis. 2008 Nov 13; 7:44. and http://www.ergo-log.com/irvingiagabonensistriple.html
